GPi‐DBS in Huntington's disease: Results on motor function and cognition in a 72‐year‐old case
Identifieur interne : 002829 ( Main/Exploration ); précédent : 002828; suivant : 002830GPi‐DBS in Huntington's disease: Results on motor function and cognition in a 72‐year‐old case
Auteurs : Alfonso Fasano [Italie] ; Paolo Mazzone [Italie] ; Carla Piano [Italie] ; Davide Quaranta [Italie] ; Francesco Soleti [Italie] ; Anna Rita Bentivoglio [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-07-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Chirurgie.
English descriptors
- KwdEn :
- Aged, Cognition, Cognition (physiology), Deep Brain Stimulation (methods), Deep brain stimulation, Globus Pallidus (physiology), Globus pallidus, Humans, Huntington Disease (physiopathology), Huntington Disease (therapy), Huntington disease, Huntington's disease, Male, Motor Activity (physiology), Nervous system diseases, Surgery, Treatment, Treatment Outcome, deep brain stimulation, surgery, therapy.
- MESH :
- methods : Deep Brain Stimulation.
- physiology : Cognition, Globus Pallidus, Motor Activity.
- physiopathology : Huntington Disease.
- therapy : Huntington Disease.
- Aged, Humans, Male, Treatment Outcome.
Abstract
Huntington's disease (HD) produces debilitating motor abnormalities that are poorly responsive to medical therapy. Deep brain stimulation (DBS) of the posteroventral globus pallidus internus (GPi) may offer a treatment option for patients with diskinetic phenotype and minimal cognitive impairment, but its role in the management of HD remains unclear and to date only two cases have been reported. We report the outcome of GPi‐DBS in a 72‐year‐old man with HD. Stimulation at 130 Hz caused a rapid amelioration of chorea producing the worsening of bradykinesia, whereas 40 Hz stimulation (maintaining constant the total electrical energy delivered) improved chorea while preserving the ability to walk. At 1‐year follow‐up, chorea has completely disappeared; however, the patient was unable to stand and walk. The cognitive profile showed a progressive deterioration, with an extension of deficit from the mainly dysexecutive alterations at baseline to a more diffused cognitive deterioration. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22116
Affiliations:
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Le document en format XML
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Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Neurologia, Università Cattolica del Sacro Cuore, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-07-15">2008-07-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1289">1289</biblScope><biblScope unit="page" to="1292">1292</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">67A527369FFB595BC8682FB98A344BCF75B11039</idno><idno type="DOI">10.1002/mds.22116</idno><idno type="ArticleID">MDS22116</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cognition</term><term>Cognition (physiology)</term><term>Deep Brain Stimulation (methods)</term><term>Deep brain stimulation</term><term>Globus Pallidus (physiology)</term><term>Globus pallidus</term><term>Humans</term><term>Huntington Disease (physiopathology)</term><term>Huntington Disease (therapy)</term><term>Huntington disease</term><term>Huntington's disease</term><term>Male</term><term>Motor Activity (physiology)</term><term>Nervous system diseases</term><term>Surgery</term><term>Treatment</term><term>Treatment Outcome</term><term>deep brain stimulation</term><term>surgery</term><term>therapy</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term><term>Globus Pallidus</term><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Male</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chirurgie</term><term>Chorée de Huntington</term><term>Cognition</term><term>Pathologie du système nerveux</term><term>Stimulation cérébrale profonde</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Huntington's disease (HD) produces debilitating motor abnormalities that are poorly responsive to medical therapy. Deep brain stimulation (DBS) of the posteroventral globus pallidus internus (GPi) may offer a treatment option for patients with diskinetic phenotype and minimal cognitive impairment, but its role in the management of HD remains unclear and to date only two cases have been reported. We report the outcome of GPi‐DBS in a 72‐year‐old man with HD. Stimulation at 130 Hz caused a rapid amelioration of chorea producing the worsening of bradykinesia, whereas 40 Hz stimulation (maintaining constant the total electrical energy delivered) improved chorea while preserving the ability to walk. At 1‐year follow‐up, chorea has completely disappeared; however, the patient was unable to stand and walk. The cognitive profile showed a progressive deterioration, with an extension of deficit from the mainly dysexecutive alterations at baseline to a more diffused cognitive deterioration. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name></region><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><name sortKey="Mazzone, Paolo" sort="Mazzone, Paolo" uniqKey="Mazzone P" first="Paolo" last="Mazzone">Paolo Mazzone</name><name sortKey="Piano, Carla" sort="Piano, Carla" uniqKey="Piano C" first="Carla" last="Piano">Carla Piano</name><name sortKey="Quaranta, Davide" sort="Quaranta, Davide" uniqKey="Quaranta D" first="Davide" last="Quaranta">Davide Quaranta</name><name sortKey="Soleti, Francesco" sort="Soleti, Francesco" uniqKey="Soleti F" first="Francesco" last="Soleti">Francesco Soleti</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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